Distribution in the brain and possible neuroprotective effects of intranasally delivered multi-walled carbon nanotubes.

ABSTRACT: Carbon nanotubes (CNTs) are currently under active investigation for their use in several biomedical applications, especially in neurological diseases and nervous system injury due to their electrochemical properties. Nowadays, no CNT-based therapeutic products for internal use appear to be close to the market, due to the still limited knowledge on their fate after delivery to living organisms and, in particular, on their toxicological profile. The purpose of the present work was to address the distribution in the brain parenchyma of two intranasally delivered MWCNTs (MWCNTs 1 and a-MWCNTs 2), different from each other, the first being non electroconductive while the second results in being electroconductive. After intranasal delivery, the presence of CNTs was investigated in several brain

SUBMITTER: Soligo M 

PROVIDER: S-EPMC9418508 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature