Fluorescence enhanced lab-on-a-chip patterned using a hybrid technique of femtosecond laser direct writing and anodized aluminum oxide porous nanostructuring.

ABSTRACT: In this paper, we demonstrate a simple yet effective hybrid method to fabricate lab-on-a-chip devices on aluminum (Al) foil. Instead of using conventional photoresists and lithography methods, an array of square units is first produced by femtosecond laser direct writing, followed by generating highly ordered anodized aluminum oxide (AAO) nanoporous structures within each unit. The AAO treated area becomes hydrophilic. Next, we functionalize the surrounding area outside the square units to superhydrophobic by electrochemical deposition and further chemical modification. This hydrophilic and hydrophobic pattern allows us to confine the liquid samples to be detected within the hydrophilic AAO detection area. We use rhodamine 6G (R6G) as a probe, and obtain a fluorescence intensity enhancemen

SUBMITTER: Yu Z 

PROVIDER: S-EPMC9418693 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature