Single-cell RNA sequencing depicts the local cell landscape in thyroid-associated ophthalmopathy.

ABSTRACT: There is a specific reactivity and characteristic remodeling of the periocular tissue in thyroid-associated ophthalmopathy (TAO). However, local cell changes responsible for these pathological processes have not been sufficiently identified. Here, single-cell RNA sequencing is performed to characterize the transcriptional changes of cellular components in the orbital connective tissue in individuals with TAO. Our study shows that lipofibroblasts with RASD1 expression are highly involved in inflammation and adipogenesis during TAO. ACKR1⁺ endothelial cells and adipose tissue macrophages may engage in TAO pathogenesis. We find CD8⁺CD57⁺ cytotoxic T lymphocytes with the terminal differentiation phenotype to be another source of interferon-γ, a molecule activel

SUBMITTER: Li Z 

PROVIDER: S-EPMC9418739 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature