A nano-integrated diagnostic and therapeutic platform with oxidation-reduction reactions in tumor microenvironments.

ABSTRACT: In the present study, we developed a nano-integrated diagnostic and therapeutic platform with oxidation-reduction reactions in tumor microenvironments (TMEs). The proposed platform resolved the contradiction of particle size between the enhanced permeability and retention (EPR) effect and tumor interstitial penetration, as well as poor circulation and low drug-loading efficiency. Flower-like MnO₂ NPs were used as the core and modified with hyaluronate (HA) and H₂PtCl₆ to obtain MnO₂-HA@H₂PtCl₆ (MHP). The maximum drug-loading efficiency rate of H₂PtCl₆ reached 35% due to its chelation with HA. MHP showed satisfactory integrity and stability during circulation and can also be used as a magnetic resonance

SUBMITTER: Zhao L 

PROVIDER: S-EPMC9418791 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature