Identification of clinical and ecological determinants of strain engraftment after fecal microbiota transplantation using metagenomics.

ABSTRACT: Fecal microbiota transplantation (FMT) is a promising therapeutic approach for microbiota-associated pathologies, but our understanding of the post-FMT microbiome assembly process and its ecological and clinical determinants is incomplete. Here we perform a comprehensive fecal metagenome analysis of 14 FMT trials, involving five pathologies and >250 individuals, and determine the origins of strains in patients after FMT. Independently of the underlying clinical condition, conspecific coexistence of donor and recipient strains after FMT is uncommon and donor strain engraftment is strongly positively correlated with pre-FMT recipient microbiota dysbiosis. Donor strain engraftment was enhanced through antibiotic pretreatment and bowel lavage and dependent on donor and recipient ɑ-diversity; s

SUBMITTER: Podlesny D 

PROVIDER: S-EPMC9418803 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature