A near infrared dye-coated silver nanoparticle/carbon dot nanocomposite for targeted tumor imaging and enhanced photodynamic therapy.

ABSTRACT: An excellent photosensitizer for imaging-guided high efficiency photodynamic therapy (PDT) requires certain features, such as near-infrared (NIR) light emission, high singlet-to-triplet intersystem crossing (ISC) efficiency, and tumor targeting. However, synthetizing photosensitizers that meet the aforementioned characteristics still remains a challenge. In this study, we synthetized a NIR dye (CyOH)-coated silver nanoparticle/carbon dot nanocomposite (CyOH-AgNP/CD) as a novel nanophotosensitizer for targeted tumor imaging and high-efficiency PDT. The CyOH-AgNP/CD nanophotosensitizer was constructed using a NIR dye (CyOH) and an AgNP/CD nanohybrid via Ag-O interaction. Relative to the AgNP/CD nanohybrid, CyOH-AgNP/CD exhibited a high singlet oxygen yield, mitochondrial accumulation,

SUBMITTER: Liu R 

PROVIDER: S-EPMC9418805 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature