Composition and organization of kinetochores show plasticity in apicomplexan chromosome segregation.

ABSTRACT: Kinetochores are multiprotein assemblies directing mitotic spindle attachment and chromosome segregation. In apicomplexan parasites, most known kinetochore components and associated regulators are apparently missing, suggesting a minimal structure with limited control over chromosome segregation. In this study, we use interactomics combined with deep homology searches to identify 13 previously unknown components of kinetochores in Apicomplexa. Apicomplexan kinetochores are highly divergent in sequence and composition from animal and fungal models. The nanoscale organization includes at least four discrete compartments, each displaying different biochemical interactions, subkinetochore localizations and evolutionary rates across the phylum. We reveal alignment of kinetochores at the metapha

SUBMITTER: Brusini L 

PROVIDER: S-EPMC9418836 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature