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Rechargeable polyamide-based N-halamine nanofibrous membranes for renewable, high-efficiency, and antibacterial respirators.

ABSTRACT: Emerging infectious diseases (EIDs) have been acknowledged as a major public health concern worldwide. Unfortunately, most protective respirators used to prevent EID transmission suffer from the disadvantage of lacking antimicrobial activity, leading to an increased risk of cross-contamination and post-infection. Herein, we report a novel and facile strategy to fabricate rechargeable and biocidal air filtration materials by creating advanced N-halamine structures based on electrospun polyamide (PA) nanofibers. Our approach can endow the resultant nanofibrous membranes with powerful biocidal activity (6 log CFU reduction against E. coli), an ultrahigh fine particle capture efficiency of 99.999% (N100 level for masks), and can allow the antibacterial efficacy and air filtration performance to be renewed in a one-step chlorination process, which has never been reported before. More importantly, for the first time, we revealed the synergistic effect involving the intrinsic structure of polymers and the assembling structure of nanofibers on the chlorination capacity. The successful fabrication of such a fascinating membrane can provide new insights into the development of nanofibrous materials in a multifunctional, durable, and renewable form.

SUBMITTER: Wang R

PROVIDER: S-EPMC9418896 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Rechargeable polyamide-based <i>N</i>-halamine nanofibrous membranes for renewable, high-efficiency, and antibacterial respirators.

Wang Ru R Li Yuyao Y Si Yang Y Wang Fei F Liu Yitao Y Ma Ying Y Yu Jianyong J Yin Xia X Ding Bin B

Nanoscale advances 20190325 5

Emerging infectious diseases (EIDs) have been acknowledged as a major public health concern worldwide. Unfortunately, most protective respirators used to prevent EID transmission suffer from the disadvantage of lacking antimicrobial activity, leading to an increased risk of cross-contamination and post-infection. Herein, we report a novel and facile strategy to fabricate rechargeable and biocidal air filtration materials by creating advanced <i>N</i>-halamine structures based on electrospun poly ...[more]

PMID: 36134243

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Project description:In this research work, nanofibrous hybrids are manufactured, characterized, and assessed as active antiviral and antibacterial membranes. In more detail, both polyvinyl alcohol (PVA) and thermoplastic polyurethane (TPU) nanofibrous (NF) membranes and their composites with embedded silver nanoparticles (Ag NPs) are manufactured by an electrospinning process. Their morphological structures have been investigated by a scanning electron microscope (SEM) which revealed a homogenous distribution and almost beads-free fibers in all manufactured samples. Characterization with spectroscopic tools has been performed and proved the successful manufacturing of Ag-incorporated PVA and TPU hybrid nanofibers. The crystalline phase of the nanofibers has been determined using an X-ray diffractometer (XRD) whose patterns showed their crystalline nature at an angle value (2θ) of less than 20°. Subsequent screening of both antiviral and antibacterial potential activities of developed nanohybrid membranes has been explored against different viruses, including SARS-Cov-2 and some bacterial strains. As a novel approach, the current work highlights potential effects of several polymeric hybrids on antiviral and antibacterial activities particularly against SARS-Cov-2. Moreover, two types of polymers have been tested and compared; PVA of excellent biodegradable and hydrophilic properties, and TPU of excellent mechanical, super elasticity, hydrophobicity, and durability properties. Such extreme polymers can serve a wide range of applications such as PPE, filtration, wound healing, etc. Consequently, assessment of their antiviral/antibacterial activities, as host matrices for Ag NPs, is needed for different medical applications. Our results showed that TPU-Ag was more effective than PVA-Ag as HIV-1 antiviral nanohybrid as well as in deactivating spike proteins of SARS-Cov-2. Both TPU-Ag and PVA-Ag nanofibrous membranes were found to have superior antimicrobial performance by increasing Ag concentration from 2 to 4 wt.%. Additionally, the developed membranes showed acceptable physical and mechanical properties along with both antiviral and antibacterial activities, which can enable them to be used as a promising functional layer in Personal Protective Equipment (PPE) such as (surgical gowns, gloves, overshoes, hair caps, etc.). Therefore, the developed functional membranes can support the decrease of both coronavirus spread and bacterial contamination, particularly among healthcare professionals within their workplace settings.

Dataset Information

Rechargeable polyamide-based N-halamine nanofibrous membranes for renewable, high-efficiency, and antibacterial respirators.

Publications

Rechargeable polyamide-based <i>N</i>-halamine nanofibrous membranes for renewable, high-efficiency, and antibacterial respirators.

Similar Datasets

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