Rutile nano-bio-interactions mediate dissimilar intracellular destiny in human skin cells.

ABSTRACT: The use of nanoparticles (NPs) in the healthcare market is growing exponentially, due to their unique physicochemical properties. Titanium dioxide nanoparticles (TiO₂ NPs) are used in the formulation of sunscreens, due to their photoprotective capacity, but interactions of these particles with skin cells on the nanoscale are still unexplored. In the present study we aimed to determine whether the initial nano-biological interactions, namely the formation of a nano-bio-complex (other than the protein corona), can predict rutile internalization and intracellular trafficking in primary human fibroblasts and keratinocytes. Results showed no significant effect of NPs on fibroblast and keratinocyte viability, but cell proliferation was possibly compromised due to nano-bio-interactions

SUBMITTER: Sanches PL 

PROVIDER: S-EPMC9418931 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature