Impact of sex and sex hormones on pathophysiology and progression of aortic stenosis in a murine model.

ABSTRACT: The lesions observed in AS have been shown to be sex specific, with women presenting extensive fibrotic remodeling while men developing more calcification deposit. We thus aimed to evaluate the influence of sex and sex hormones on the pathophysiology of aortic valve stenosis (AS) in our mouse model of AS. LDLr^-/- ApoB^100/100 IGF-II^+/- mice (n = 210) were separated in six different groups: (1) intact male (IM), (2) intact female (IF), (3) castrated male (CM), (4) ovariectomized females (OF), (5) CM with testosterone supplementation (CMT), and (6) OF with 17β-estradiol supplementation (OFE). Mice were fed a high-fat/high-sucrose/high-cholesterol diet for 6 months. Hemodynamic progression of AS was followed by transthoracic echocardiography (at 12 and 36 weeks

SUBMITTER: Fleury MA 

PROVIDER: S-EPMC9419154 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature