Three-dimensional models of the cervicovaginal epithelia to study host-microbiome interactions and sexually transmitted infections.

ABSTRACT: 2D cell culture systems have historically provided controlled, reproducible means to analyze host-pathogen interactions observed in the human reproductive tract. Although inexpensive, straightforward, and requiring a very short time commitment, these models recapitulate neither the functionality of multilayered cell types nor the associated microbiome that occurs in a human. Animal models have commonly been used to recreate the complexity of human infections. However, extensive modifications of animal models are required to recreate interactions that resemble those in the human reproductive tract. 3D cell culture models have emerged as alternative means of reproducing vital elements of human infections at a fraction of the cost of animal models and on a scale that allows for replicative ex

SUBMITTER: Edwards VL 

PROVIDER: S-EPMC9419571 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature