Ultrasensitive two-dimensional material-based MCF-7 cancer cell sensor driven by perturbation processes.

ABSTRACT: Changes in lipid composition and structure during cell development can be markers for cell apoptosis or various diseases such as cancer. Although traditional fluorescence techniques utilising molecular probes have been studied, these methods are limited in studying these micro-changes as they require complex probe preparation and cannot be reused, making cell monitoring and detection challenging. Here, we developed a direct current (DC) resistance sensor based on two-dimensional (2D) molybdenum disulfide (MoS₂) nanosheets to enable cancer cell-specific detection dependent on micro-changes in the cancer cell membrane. Atomistic molecular dynamics (MD) simulations were used to study the interaction between 2D MoS₂ and cancer lipid bilayer systems, and revealed that prev

SUBMITTER: Chan SSY 

PROVIDER: S-EPMC9419592 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature