Staphylococcus aureus entanglement in self-assembling β-peptide nanofibres decorated with vancomycin.

ABSTRACT: The increasing resistance of pathogenic microbes to antimicrobials and the shortage of antibiotic drug discovery programs threaten the clinical use of antibiotics. This threat calls for the development of new methods for control of drug-resistant microbial pathogens. We have designed, synthesised and characterised an antimicrobial material formed via the self-assembly of a population of two distinct β-peptide monomers, a lipidated tri-β-peptide (β³-peptide) and a novel β³-peptide conjugated to a glycopeptide antibiotic, vancomycin. The combination of these two building blocks resulted in fibrous assemblies with distinctive structures determined by atomic force microscopy and electron microscopy. These fibres inhibited the growth of methicillin resistant Stap

SUBMITTER: Payne JAE 

PROVIDER: S-EPMC9419598 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature