Metal-enhancement study of dual functional photosensitizers with aggregation-induced emission and singlet oxygen generation.

ABSTRACT: Photosensitizers with aggregation-induced emission (AIE-PS) are attractive for image-guided photodynamic therapy due to their dual functional role in generating singlet oxygen and producing high fluorescent signal in the aggregated state. However, their brightness and treatment efficiency maybe limited in current practice. Herein we report the first systematic investigation on the metal-enhanced fluorescence (MEF) and singlet oxygen generation (ME-SOG) ability of our newly synthesized AIE-photosensitizers. The Ag@AIE-PS of varied sizes were prepared via layer-by-layer assembly with controlled distance between silver nanoparticles (AgNPs) and AIE-PS. A maximum of 6-fold enhancement in fluorescence and 2-fold increment in SOG were observed for the 85nmAg@AIE-PS. Comprehensive characte

SUBMITTER: Tavakkoli Yaraki M 

PROVIDER: S-EPMC9419615 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature