Graphene quantum dots in photodynamic therapy.

ABSTRACT: Graphene quantum dots (GQDs) have shown great promise in a variety of medical applications. Recently, it has been found that GQDs are also beneficial for photodynamic therapy (PDT). However, the findings of GQDs as PDT agents have been controversial in the literature. Herein, we investigate the photoactivity of single-atomic-layered GQDs by examining their ability to generate singlet oxygen (¹O₂) under irradiation and their effects on the photoactivity of photosensitizers. We demonstrate that the GQDs with lateral sizes of ∼5 or 20 nm are photo-inactive for they cannot generate ¹O₂ under irradiation of either a 660 nm laser (105 mW cm^-2) or a halogen light. Moreover, the GQDs inhibit the photoactivity of two classical photosensitizers,

SUBMITTER: Chen J 

PROVIDER: S-EPMC9419651 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature