OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage.

ABSTRACT: Tuft cells are a rare chemosensory lineage that coordinates immune and neural responses to foreign pathogens in mucosal tissues¹. Recent studies have also revealed tuft-cell-like human tumours^2,3, particularly as a variant of small-cell lung cancer. Both normal and neoplastic tuft cells share a genetic requirement for the transcription factor POU2F3 (refs. ^2,4), although the transcriptional mechanisms that generate this cell type are poorly understood. Here we show that binding of POU2F3 to the uncharacterized proteins C11orf53 and COLCA2 (renamed here OCA-T1/POU2AF2 and OCA-T2/POU2AF3, respectively) is critical in the tuft cell lineage. OCA-T1 and OCA-T2 are paralogues of the B-cell-specific coactivator OCA-B; all three proteins are encoded in a gene clust

SUBMITTER: Wu XS 

PROVIDER: S-EPMC9419707 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature