Controllable synthesis of variable-sized magnetic nanocrystals self-assembled into porous nanostructures for enhanced cancer chemo-ferroptosis therapy and MR imaging.

ABSTRACT: Magnetic-based nanomaterials are promising for cancer diagnosis and treatment. Herein, we develop a self-assembled approach for the preparation of a porous magnetic nanosystem, DOX/Mn(0.25)-Fe₃O₄-III NPs, which can simultaneously achieve chemotherapy, ferroptosis therapy and MRI to improve the therapeutic efficacy. By tuning its porous structures, whole particle sizes and compositions, this nanosystem possesses both a high drug loading capacity and excellent Fenton reaction activity. Owing to the synergetic catalysis effect of iron and manganese ions, the Fenton catalytic activity of Mn(0.25)-Fe₃O₄-III NPs (K _cat = 1.2209 × 10^-2 min^-1) was six times higher than that of pure porous Fe₃O₄

SUBMITTER: Xu J 

PROVIDER: S-EPMC9419831 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature