Differential copper-guided architectures of amyloid β peptidomimetics modulate oxidation states and catalysis.

ABSTRACT: Orchestration of differential architectures of designer peptidomimetics that modulate metal oxidation states to perform multiple chemical transformations remains a challenge. Cu-chelation and self-assembly properties of amyloid β (Aβ14-23) peptide were tuned by the incorporation of cyclic dipeptide (CDP) and pyrene (Py) as the assembly directing and reporting units, respectively. We explore the molecular architectonics of Aβ14-23 derived peptidomimetics (Akd^NMCPy) to form differential architectures that stabilize distinct Cu oxidation states. The fibrillar self-assembly of Akd^NMCPy is modulated to form nanosheets by the one-off addition of Cu^II. Notably, the serial addition of Cu^II resulted in the formation of micelle-like core-shell architecture

SUBMITTER: Ghosh D 

PROVIDER: S-EPMC9419866 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature