Exploiting Dentine Matrix Proteins in Cell-Free Approaches for Periradicular Tissue Engineering.

ABSTRACT: The recent discovery of mesenchymal stem cells within periapical lesions (PL-MSC) has presented novel opportunities for managing periradicular diseases in adult teeth by way of enhancing tissue regeneration. This discovery coincides with the current paradigm shift toward biologically driven treatment strategies in endodontics, which have typically been reserved for non-vital immature permanent teeth. One such approach that shows promise is utilizing local endogenous non-collagenous dentine extracellular matrix components (dECM) to recruit and upregulate the intrinsic regenerative capacity of PL-MSCs in situ. At picogram levels, these morphogens have demonstrated tremendous ability to enhance the cellular activities in in vitro and in vivo animal studies that would othe

SUBMITTER: Virdee SS 

PROVIDER: S-EPMC9419954 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature