Brain volume abnormalities and clinical outcomes following paediatric traumatic brain injury.

ABSTRACT: Long-term outcomes are difficult to predict after paediatric traumatic brain injury. The presence or absence of focal brain injuries often do not explain cognitive, emotional and behavioural disabilities that are common and disabling. In adults, traumatic brain injury produces progressive brain atrophy that can be accurately measured and is associated with cognitive decline. However, the effect of paediatric traumatic brain injury on brain volumes is more challenging to measure because of its interaction with normal brain development. Here we report a robust approach to the individualized estimation of brain volume following paediatric traumatic brain injury and investigate its relationship to clinical outcomes. We first used a large healthy control dataset (n > 1200, age 8-22) to describe

SUBMITTER: Bourke NJ 

PROVIDER: S-EPMC9420021 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature