Metabolite biomarker discovery for human gastric cancer using dried blood spot mass spectrometry metabolomic approach.

ABSTRACT: As one of the most common malignancies, gastric cancer (GC) is the third leading cause of cancer-related deaths in China. GC is asymptomatic in early stages, and the majority of GC mortality is due to delayed symptoms. It is an urgent task to find reliable biomarkers for the identification of GC in order to improve outcomes. A combination of dried blood spot sampling and direct infusion mass spectrometry (MS) technology was used to measure blood metabolic profiles for 166 patients with GC and 183 healthy individuals, and 93 metabolites including amino acids, carnitine/acylcarnitines and their derivatives, and related ratios were quantified. Multiple algorithms were used to characterize the changes of metabolic profiles in patients with GC compared to healthy individuals. A biomarker panel

SUBMITTER: Wu X 

PROVIDER: S-EPMC9420103 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature