Epidemiological and viral characteristics of undiagnosed HIV infections in Botswana.

ABSTRACT:

Background

HIV-1 is endemic in Botswana. The country's primary challenge is identifying people living with HIV who are unaware of their status. We evaluated factors associated with undiagnosed HIV infection using HIV-1 phylogenetic, behavioural, and demographic data.

Methods

As part of the Botswana Combination Prevention Project, 20% of households in 30 villages were tested for HIV and followed from 2013 to 2018. A total of 12,610 participants were enrolled, 3596 tested HIV-positive at enrolment, and 147 participants acquired HIV during the trial. Extensive socio-demographic and behavioural data were collected from participants and next-generation sequences were generated for HIV-positive cases. We compared three groups of participants: (1) those previously known to be HIV-p

SUBMITTER: Bhebhe L 

PROVIDER: S-EPMC9420270 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature