Hepatitis B and C virus infections and the risk of biliary tract cancers: a meta-analysis of observational studies.

ABSTRACT:

Background

Both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are important risk factors for hepatocellular carcinoma. However, their effect on other hepatobiliary cancers, such as biliary tract cancers (BTCs), is not well established. We aimed to investigate associations between HBV or HCV infection and BTCs risk by conducting a systematic review and meta-analysis.

Methods

We searched PubMed to identify all relevant articles published before June 9, 2021. Meta-analysis was performed to calculate pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs). The meta-analysis was evaluated by heterogeneity testing, sensitivity analyses, and publication bias assessment.

Results

In total, 48 articles involving 69,723 cases and 4,047,574 cont

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9420284 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature