IL-34 deficiency impairs FOXP3⁺ Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis.

ABSTRACT:

Background

Immune homeostasis requires fully functional Tregs with a stable phenotype to control autoimmunity. Although IL-34 is a cytokine first described as mainly involved in monocyte cell survival and differentiation, we recently described its expression by CD8⁺ Tregs in a rat model of transplantation tolerance and by activated FOXP3⁺ CD4⁺ and CD8⁺ Tregs in human healthy individuals. However, its role in autoimmunity and potential in human diseases remains to be determined.

Methods

We generated Il34^-/- rats and using both Il34^-/- rats and mice, we investigated their phenotype under inflammatory conditions. Using Il34^-/- rats, we further analyzed the impact of the absence of expression of IL-34 f

SUBMITTER: Freuchet A 

PROVIDER: S-EPMC9420423 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature