Influence of childhood adversity, approach motivation traits, and depression on individual differences in brain activation during reward anticipation.

ABSTRACT: Reward anticipation dysfunction is associated with major depressive disorder (MDD), but is not universally observed in individuals with MDD. Reward anticipation deficits have also been linked to childhood adversity (CA) and approach/avoidance traits. The present study evaluated whether severity of CA (as measured by the Childhood Trauma Questionnaire) and approach/avoidance traits predict individual differences in blood oxygen level dependent (BOLD) response to reward anticipation beyond MDD diagnosis alone. Participants were individuals with MDD (n = 23) and healthy controls (n = 27). Multiple regression was conducted using CTQ scores, trait approach/avoidance scores, and diagnosis to predict activation during reward anticipation in a monetary incentive delay fMRI task. Across groups, hig

SUBMITTER: DelDonno SR 

PROVIDER: S-EPMC9420556 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature