5-HT₇ receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome.

ABSTRACT: Irritable bowel syndrome (IBS) is characterized by visceral hypersensitivity (VH) associated with abnormal serotonin/5-hydroxytryptamine (5-HT) metabolism and neurotrophin-dependent mucosal neurite outgrowth. The underlying mechanisms of VH remain poorly understood. We investigated the role of 5-HT₇ receptor in mucosal innervation and intestinal hyperalgesia. A high density of mucosal nerve fibres stained for 5-HT₇ was observed in colonoscopic biopsy specimens from IBS patients compared with those from healthy controls. Staining of 5-HT₃ and 5-HT₄ receptors was observed mainly in colonic epithelia with comparable levels between IBS and controls. Visceromotor responses to colorectal distension were evaluated in two mouse models, one postinfectious

SUBMITTER: Chang WY 

PROVIDER: S-EPMC9420680 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature