Kinetic analysis of multi-resolution hyperpolarized ¹³ C human brain MRI to study cerebral metabolism.

ABSTRACT:

Purpose

To investigate multi-resolution hyperpolarized (HP) ¹³ C pyruvate MRI for measuring kinetic conversion rates in the human brain.

Methods

HP [1-¹³ C]pyruvate MRI was acquired in 6 subjects with a multi-resolution EPI sequence at 7.5 × 7.5 mm² resolution for pyruvate and 15 × 15 mm² resolution for lactate and bicarbonate. With the same lactate data, 2 quantitative maps of pyruvate-to-lactate conversion (k_PL ) maps were generated: 1 using 7.5 × 7.5 mm² resolution pyruvate data and the other using synthetic 15 × 15 mm² resolution pyruvate data to simulate a standard constant resolution acquisition. To examine local k_PL values, 4 voxels were manually selected in each study representing

SUBMITTER: Hu JY 

PROVIDER: S-EPMC9420752 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature