Association of cognition with leptin and vascular endothelial growth factor in individuals with type 2 diabetes mellitus.

ABSTRACT:

Objective

The 10-year intensive lifestyle intervention (ILI) of the Look AHEAD study left a legacy of relative deficits in cognitive function among participants who entered the clinical trial with obesity or a history of cardiovascular disease. We hypothesized that altered levels of two weight-sensitive proangiogenic cytokines, leptin and vascular endothelial growth factor (VEGF), accounted for this concerning finding.

Methods

Serum leptin and VEGF concentrations were determined in 1,279 Look AHEAD participants at baseline, proximal to cessation of the interventions (Epoch 1), and an average of 4 years later (Epoch 2). Up to four standardized assessments of attention, executive function, and memory were collected during follow-up. Mixed effects models were used to assess rel

SUBMITTER: Espeland MA 

PROVIDER: S-EPMC9420754 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature