Compartmentalization and regulation of GTP in control of cellular phenotypes.
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ABSTRACT:
SUBMITTER: Wolff DW
PROVIDER: S-EPMC9420775 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Compartmentalization and regulation of GTP in control of cellular phenotypes.
Wolff David W DW Bianchi-Smiraglia Anna A Nikiforov Mikhail A MA
Trends in molecular medicine 20220616 9
Genetic or pharmacological inhibition of enzymes involved in GTP biosynthesis has substantial biological effects, underlining the need to better understand the function of GTP levels in regulation of cellular processes and the significance of targeting GTP biosynthesis enzymes for therapeutic intervention. Our current understanding of spatiotemporal regulation of GTP metabolism and its role in physiological and pathological cellular processes is far from complete. Novel methodologies such as gen ...[more]
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