Dataset Information

Water intake, thirst, and copeptin responses to two dehydrating stimuli in lean men and men with obesity.

ABSTRACT:

Objective

Physiological systems responsible for water homeostasis and energy metabolism are interconnected. This study hypothesized altered responses to dehydration including thirst, ad libitum water intake, and copeptin in men with obesity.

Methods

Forty-two men (22 lean and 20 with obesity) were stimulated by a 2-hour hypertonic saline infusion and a 24-hour water deprivation. In each dehydrating condition, thirst, ad libitum water intake after dehydration, and urinary and hormonal responses including copeptin were assessed.

Results

After each dehydration condition, ad libitum water intake was similar between both groups (p > 0.05); however, those with obesity reported feeling less thirsty (p < 0.05) and had decreased copeptin response and higher urinary sodium concentrations when stressed (p < 0.05). Angiotensin II, aldosterone, atrial and brain natriuretic peptides, and apelin concentrations did not differ by adiposity group and did not explain the different thirst or copeptin responses in men with obesity. However, leptin was associated with copeptin response in lean individuals during the hypertonic saline infusion (p < 0.05), but the relationship was diminished in those with obesity.

Conclusions

Diminished thirst and copeptin responses are part of the obesity phenotype and may be influenced by leptin. Adiposity may impact pathways regulating thirst and vasopressin release, warranting further investigation.

SUBMITTER: Chang DC

PROVIDER: S-EPMC9420804 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Water intake, thirst, and copeptin responses to two dehydrating stimuli in lean men and men with obesity.

Chang Douglas C DC Penesova Adela A Bunt Joy C JC Stinson Emma J EJ Kavouras Stavros A SA Gluck Marci E ME Paddock Ethan E Walter Mary M Piaggi Paolo P Krakoff Jonathan J

Obesity (Silver Spring, Md.) 20220802 9

<h4>Objective</h4>Physiological systems responsible for water homeostasis and energy metabolism are interconnected. This study hypothesized altered responses to dehydration including thirst, ad libitum water intake, and copeptin in men with obesity.<h4>Methods</h4>Forty-two men (22 lean and 20 with obesity) were stimulated by a 2-hour hypertonic saline infusion and a 24-hour water deprivation. In each dehydrating condition, thirst, ad libitum water intake after dehydration, and urinary and hormo ...[more]

PMID: 35918877

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Dataset Information

Water intake, thirst, and copeptin responses to two dehydrating stimuli in lean men and men with obesity.

Objective

Methods

Results

Conclusions

Publications

Water intake, thirst, and copeptin responses to two dehydrating stimuli in lean men and men with obesity.

Similar Datasets

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