Water intake, thirst, and copeptin responses to two dehydrating stimuli in lean men and men with obesity.

ABSTRACT:

Objective

Physiological systems responsible for water homeostasis and energy metabolism are interconnected. This study hypothesized altered responses to dehydration including thirst, ad libitum water intake, and copeptin in men with obesity.

Methods

Forty-two men (22 lean and 20 with obesity) were stimulated by a 2-hour hypertonic saline infusion and a 24-hour water deprivation. In each dehydrating condition, thirst, ad libitum water intake after dehydration, and urinary and hormonal responses including copeptin were assessed.

Results

After each dehydration condition, ad libitum water intake was similar between both groups (p > 0.05); however, those with obesity reported feeling less thirsty (p < 0.05) and had decreased copeptin response and higher urinary sodium conc

SUBMITTER: Chang DC 

PROVIDER: S-EPMC9420804 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature