Placental protein levels in maternal serum are associated with adverse pregnancy outcomes in nulliparous patients.

ABSTRACT:

Background

The Eunice Kennedy Shriver National Institute of Child Health and Human Development Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be was established to investigate the underlying causes and pathophysiological pathways associated with adverse pregnancy outcomes in nulliparous gravidas.

Objective

This study aimed to study placental physiology and identify novel biomarkers concerning adverse pregnancy outcomes, including preterm birth (medically indicated and spontaneous), preeclampsia, small-for-gestational-age neonates, and stillbirth. We measured levels of placental proteins in the maternal circulation in the first 2 trimesters of pregnancy.

Study design

Maternal serum samples were collected at 2 study visits (6-13 weeks and 16-21 weeks), and

SUBMITTER: Parry S 

PROVIDER: S-EPMC9420814 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature