Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species.

ABSTRACT: Developing an efficient antioxidant for anti-inflammatory therapy via scavenging reactive oxygen species (ROS) remains a great challenge owing to the insufficient activity and stability of traditional antioxidants. Herein, we explored and simply synthesized a biocompatible carbon dots (CDs) nanozyme with excellent scavenging activity of ROS for anti-inflammatory therapy. As expected, CDs nanozyme effectively eliminate many kinds of free radicals including ^•OH, O₂ ^•- , and ABTS⁺•. Benefiting from multienzyme activities against ROS, CDs nanozyme can decrease the levels of pro-inflammatory cytokines, resulting in good anti-inflammatory effect. Taken together, this study not only sheds light on design of bioactive antioxidants but also

SUBMITTER: Dong C 

PROVIDER: S-EPMC9420844 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature