Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming.

ABSTRACT: Stellate cells are principal neurons in the entorhinal cortex that contribute to spatial processing. They also play a role in the context of Alzheimer's disease as they accumulate Amyloid beta early in the disease. Producing human stellate cells from pluripotent stem cells would allow researchers to study early mechanisms of Alzheimer's disease, however, no protocols currently exist for producing such cells. In order to develop novel stem cell protocols, we characterize at high resolution the development of the porcine medial entorhinal cortex by tracing neuronal and glial subtypes from mid-gestation to the adult brain to identify the transcriptomic profile of progenitor and adult stellate cells. Importantly, we could confirm the robustness of our data by extracting developmental factors f

SUBMITTER: Bergmann T 

PROVIDER: S-EPMC9420913 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature