Network pharmacological analysis of active components of Xiaoliu decoction in the treatment of glioblastoma multiforme.

ABSTRACT: Background: Glioblastoma multiforme (GBM) is the most aggressive primary nervous system brain tumor. There is still a lack of effective methods to control its progression and recurrence in clinical treatment. It is clinically found that Xiaoliu Decoction (XLD) has the effect of treating brain tumors and preventing tumor recurrence. However, its mechanism is still unclear. Methods: Search the Traditional Chinese Medicine System Pharmacology Database (TCSMP) for efficient substances for the treatment of XLD in the treatment of GBM, and target the targeted genes of the effective ingredients to construct a network. At the same time, download GBM-related gene expression data from the TCGA and GTEX databases, screen differential expression bases, and establish a drug target disease

SUBMITTER: Wu J 

PROVIDER: S-EPMC9420933 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature