Serum Metabolites and Kidney Outcomes: The Atherosclerosis Risk in Communities Study.

ABSTRACT:

Rationale & objective

Novel metabolite biomarkers of kidney failure with replacement therapy (KFRT) may help identify people at high risk for adverse kidney outcomes and implicated pathways may aid in developing targeted therapeutics.

Study design

Prospective cohort.

Setting & participants

The cohort included 3,799 Atherosclerosis Risk in Communities study participants with serum samples available for measurement at visit 1 (1987-1989).

Exposure

Baseline serum levels of 318 metabolites.

Outcomes

Incident KFRT, kidney failure (KFRT, estimated glomerular filtration rate <15 mL/min/1.73 m², or death from kidney disease).

Analytical approach

Because metabolites are often intercorrelated and represent shared pathways, we used a high dimensio

SUBMITTER: Bernard L 

PROVIDER: S-EPMC9420957 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature