Identification of a novel cuproptosis-related gene signature and integrative analyses in patients with lower-grade gliomas.

ABSTRACT:

Background

Cuproptosis is a newly discovered unique non-apoptotic programmed cell death distinguished from known death mechanisms like ferroptosis, pyroptosis, and necroptosis. However, the prognostic value of cuproptosis and the correlation between cuproptosis and the tumor microenvironment (TME) in lower-grade gliomas (LGGs) remain unknown.

Methods

In this study, we systematically investigated the genetic and transcriptional variation, prognostic value, and expression patterns of cuproptosis-related genes (CRGs). The CRG score was applied to quantify the cuproptosis subtypes. We then evaluated their values in the TME, prognostic prediction, and therapeutic responses in LGG. Lastly, we collected five paired LGG and matched normal adjacent tissue samples from Sun Yat-sen Uni

SUBMITTER: Bao JH 

PROVIDER: S-EPMC9420977 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature