Identifying key genes in CD4⁺ T cells of systemic lupus erythematosus by integrated bioinformatics analysis.

ABSTRACT: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by excessive activation of T and B lymphocytes and breakdown of immune tolerance to autoantigens. Despite several mechanisms including the genetic alterations and inflammatory responses have been reported, the overall signature genes in CD4⁺ T cells and how they affect the pathological process of SLE remain to be elucidated. This study aimed to identify the crucial genes, potential biological processes and pathways underlying SLE pathogenesis by integrated bioinformatics. The gene expression profiles of isolated peripheral CD4⁺ T cells from SLE patients with different disease activity and healthy controls (GSE97263) were analyzed, and 14 co-expression modules were identified using weighte

SUBMITTER: Li Z 

PROVIDER: S-EPMC9420982 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature