Construction of a Prognostic Nomogram Based on Autophagy-Related Genes for Children With Neuroblastoma.

ABSTRACT: Neuroblastoma (NB) is the most common solid malignancy in children. MYCN gene amplification is the most relevant genetic alteration in patients with NB and is associated with poor prognosis. Autophagy plays specific roles in the occurrence, development, and progression of NB. Here, we aimed to identify and assess the prognostic effects of autophagy-related genes (ARGs) in patients with NB and MYCN gene amplification. Differentially expressed ARGs were identified in patients with NB with and without MYCN gene amplification, and the ARG expression patterns and related clinical data from the Therapeutically Applicable Research to Generate Effective Treatments database were used as the training cohort. Least absolute shrinkage and selection operator analyses were used to identify prognostic AR

SUBMITTER: Ye G 

PROVIDER: S-EPMC9421005 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature