Colorectal Cancer Cell Differentiation Trajectory Predicts Patient Immunotherapy Response and Prognosis.

ABSTRACT:

Objectives

This study aimed to investigate the differentiation state and clinical significance of colorectal cancer cells, as well as to predict the immune response and prognosis of patients based on differentiation-related genes of colorectal cancer.

Introduction

Colorectal cancer cells exhibit different differentiation states under the influence of the tumor microenvironment, which determines the cell fates.

Methods

We combined single-cell sequencing (scRNA-seq) data from The Cancer Genome Atlas source with extensive transcriptome data from the Gene Expression Omnibus database. We obtained colorectal cancer differentiation-related genes using cell trajectory analysis and developed a colorectal cancer differentiation-related gene based molecular typing and prognostic

SUBMITTER: Qin Y 

PROVIDER: S-EPMC9421035 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature