An investigation of the YidC-mediated membrane insertion of Pf3 coat protein using molecular dynamics simulations.

ABSTRACT: YidC is a membrane protein that facilitates the insertion of newly synthesized proteins into lipid membranes. Through YidC, proteins are inserted into the lipid bilayer via the SecYEG-dependent complex. Additionally, YidC functions as a chaperone in protein folding processes. Several studies have provided evidence of its independent insertion mechanism. However, the mechanistic details of the YidC SecY-independent protein insertion mechanism remain elusive at the molecular level. This study elucidates the insertion mechanism of YidC at an atomic level through a combination of equilibrium and non-equilibrium molecular dynamics (MD) simulations. Different docking models of YidC-Pf3 in the lipid bilayer were built in this study to better understand the insertion mechanism. To conduct a comple

SUBMITTER: Polasa A 

PROVIDER: S-EPMC9421054 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature