Effects of ulcerative colitis and Crohn's disease on neurodegenerative diseases: A Mendelian randomization study.

ABSTRACT: Background: Both ulcerative colitis (UC) and Crohn's disease (CD) are associated with neurodegenerative diseases (NDs) in observational studies, but the causality remains controversial. We aimed to use Mendelian randomization (MR) analysis to explore causal associations between UC and CD and NDs. Methods: We used single nucleotide polymorphisms (SNPs) associated (p < 5 × 10^-8) with UC and CD as instrumental variables (IVs) to perform the MR analysis on the risks of three NDs, namely, Alzheimer's Disease (AD), Parkinson's Disease (PD), and Amyotrophic Lateral Sclerosis (ALS). The inverse variance weighted (IVW) was the primary method and supplement with the weighted median and MR-Egger regression. Moreover, the MR-Egger intercept test, Cochran's Q test, and "

SUBMITTER: Li H 

PROVIDER: S-EPMC9421062 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature