Stereotactic body radiotherapy to defer systemic therapy in patients with oligorecurrent disease.

ABSTRACT:

Background

Patients who develop oligorecurrent disease may be treated with metastasis-directed stereotactic body radiotherapy (SBRT) to defer the start of systemic therapy and delay its potential side effects. We report oncological outcomes and patterns of failure in patients with oligorecurrent disease treated with SBRT and determine which factors impact the interval to initiation of systemic therapy.

Material/methods

This retrospective study included patients with oligorecurrent disease (≤5 lesions) from any solid organ malignancy, treated with SBRT to all metastases and no systemic therapy for a minimum one month after SBRT between 01/2014 and 12/2019. The Kaplan-Meier method was used to analyze overall survival (OS) and progression-free survival (PFS), and the cumulative

SUBMITTER: Willmann J 

PROVIDER: S-EPMC9421088 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature