Ontology highlight
ABSTRACT:
SUBMITTER: Kille B
PROVIDER: S-EPMC9421119 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Kille Bryce B Balaji Advait A Sedlazeck Fritz J FJ Nute Michael M Treangen Todd J TJ
Genome biology 20220829 1
With the arrival of telomere-to-telomere (T2T) assemblies of the human genome comes the computational challenge of efficiently and accurately constructing multiple genome alignments at an unprecedented scale. By identifying nucleotides across genomes which share a common ancestor, multiple genome alignments commonly serve as the bedrock for comparative genomics studies. In this review, we provide an overview of the algorithmic template that most multiple genome alignment methods follow. We also ...[more]