Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes.

ABSTRACT: Lymphocytes regulate the immune response by circulating between the vascular and lymphatic systems. High endothelial venules, HEVs, special blood vessels expressing selective adhesion molecules, such as PNAd and MAdCAM-1, mediate naïve lymphocyte migration from the vasculature into the lymph nodes and Peyer's patches. We have identified that DACH1 is abundantly expressed in developing HEV-type endothelial cells. DACH1 showed a restricted expression pattern in lymph node blood vessels during the late fetal and early neonatal periods, corresponding to HEV development. The proportion of MAdCAM-1⁺ and CD34⁺ endothelial cells is reduced in the lymph nodes of neonatal conventional and vascular-specific Dach1-deficient mice. Dach1-deficient lymph nodes in adult mice demonstr

SUBMITTER: Shintani A 

PROVIDER: S-EPMC9421177 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature