Metformin anticancer: Reverses tumor hypoxia induced by bevacizumab and reduces the expression of cancer stem cell markers CD44/CD117 in human ovarian cancer SKOV3 cells.
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ABSTRACT:
SUBMITTER: Fan Y
PROVIDER: S-EPMC9421358 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
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Metformin anticancer: Reverses tumor hypoxia induced by bevacizumab and reduces the expression of cancer stem cell markers CD44/CD117 in human ovarian cancer SKOV3 cells.
Fan Yuanchun Y Cheng Huimin H Liu Yueping Y Liu Shihao S Lowe Scott S Li Yaru Y Bentley Rachel R King Bethany B Tuason John Pocholo W JPW Zhou Qin Q Sun Chenyu C Zhang Hui H
Frontiers in pharmacology 20220815
<b>Background:</b> The occurrence and development of solid tumors depend on the blood supply in the tumor microenvironment (TME). Blocking angiogenesis is a new therapeutic strategy to inhibit tumor growth. The anti-angiogenic drug bevacizumab has been approved for gynecological malignancies, especially for advanced recurring cervical cancers and recurring ovarian cancers (OC). Studies in OC have shown a limited effect of bevacizumab in the general population, with a slight improvement in progre ...[more]
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