Antagonizing Sec62 function in intracellular Ca²⁺ homeostasis represents a novel therapeutic strategy for head and neck cancer.

ABSTRACT: Various cancer types including head and neck squamous cell carcinomas (HNSCC) show a frequent amplification of chromosomal region 3q26 that encodes, among others, for the SEC62 gene. Located in the ER membrane, this translocation protein is known to play a critical role as a potential driver oncogene in cancer development. High SEC62 expression levels were observed in various cancer entities and were associated with a poor outcome and increased metastatic burden. Because of its intracellular localization the SEC62 protein is poorly accessible for therapeutic antibodies, therefore a functional SEC62 knockdown represents the most promising mechanism of a potential antineoplastic targeted therapy. By stimulating the Ca²⁺ efflux from the ER lumen and thereby inc

SUBMITTER: Korner S 

PROVIDER: S-EPMC9421371 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature