TFAM expression in brown adipocytes confers obesity resistance by secreting extracellular vesicles that promote self-activation.

ABSTRACT: The occurrence of diet-induced obesity has been increasing worldwide and has become a major health concern. Mitochondria are densely distributed in brown adipose tissue and are involved in lipid consumption. Therefore, increasing energy expenditure through the activation of brown adipocytes may be a potential therapy for obesity. Our findings showed that mitochondrial transcription factor A (TFAM) homozygous transgenic (TgTg) mice had highly activated brown adipocytes and increased expression of oxidative phosphorylation, leading to resistance to obesity. Transplantation models of TFAM-expressing brown adipocytes could mimic the phenotype of TFAM TgTg mice, and proving their anti-obesity effect. We found that brown adipocytes secrete exosomes which enable self-activation in an autocrine an

SUBMITTER: Fujii M 

PROVIDER: S-EPMC9421388 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature