Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect.

ABSTRACT:

Background

The negative symptoms of schizophrenia have been proposed to reflect prefrontal cortex dysfunction. However, this proposal has not been consistently supported in functional imaging studies, which have also used executive tasks that may not capture key aspects of negative symptoms such as lack of volition.

Method

Twenty-four DSM-5 schizophrenic patients with high negative symptoms (HNS), 25 with absent negative symptoms (ANS) and 30 healthy controls underwent fMRI during performance of the Computerized Multiple Elements Test (CMET), a task designed to measure poor organization of goal directed behaviour or 'goal neglect'. Negative symptoms were rated using the PANSS and the Clinical Assessment Interview for Negative Symptoms (CAINS).

Results

On whole brain a

SUBMITTER: Fuentes-Claramonte P 

PROVIDER: S-EPMC9421442 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature