Neurite density of white matter significantly correlates with tuberous sclerosis complex disease severity.

ABSTRACT:

Objective

To assess whether white matter (WM) diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) derived measures correlate with tuberous sclerosis complex (TSC) disease severity.

Cohort and methods

A multi-shell diffusion protocol was added to the clinical MRI brain scans of thirteen patients including 6 males and 7 females with a mean ± std age of 17.2 ± 5.8 years. Fractional anisotropy (FA) and mean diffusivity (MD) were generated from DTI and neurite density index (NDI), orientation dispersion index (ODI) and free water index (fiso) were generated from NODDI. A clinical score was determined for each patient according to the existence of epilepsy, developmental delay, autism or psychiatric disorders. Whole-brain segmented WM was

SUBMITTER: Anaby D 

PROVIDER: S-EPMC9421460 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature