In-depth characterization of neuroradiological findings in a large sample of individuals with autism spectrum disorder and controls.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a group of neurodevelopmental conditions associated with quantitative differences in cortical and subcortical brain morphometry. Qualitative assessment of brain morphology provides complementary information on the possible underlying neurobiology. Studies of neuroradiological findings in ASD have rendered mixed results, and await robust replication in a sizable and independent sample.

Methods

We systematically and comprehensively assessed neuroradiological findings in a large cohort of participants with ASD and age-matched controls (total N = 620, 348 ASD and 272 controls), including 70 participants with intellectual disability (47 ASD, 23 controls). We developed a comprehensive scoring system, augmented by standardized biometric

SUBMITTER: Ambrosino S 

PROVIDER: S-EPMC9421485 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature